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Improvement in the anemia, and often the diabetes, is seen in patients treated with thiamine, hence the name of the disorder

High levels of uric acid can lead to uric acid stones or provide a "seed" for calcium oxalate stones to form around

Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]

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Factors such as disease severity, age, and comorbidities may influence the effectiveness of PRP in these patients